Contents 1 Structure 2 Function 3 Clinical significance 4 References 5 Further reading


Structure[edit] The complete cDNA of PDPR, which contains 2885 base pairs, has an open reading frame of 2634 nucleotides encoding a putative presequence of 31 amino acid residues and a mature protein of 847. Characteristics of native PDPR include ability to decrease the sensitivity of the catalytic subunit to Mg2+, and reversal of this inhibitory effect by the polyamine spermine. A BLAST search of protein databases revealed that PDPr is distantly related to the mitochondrial flavoprotein dimethylglycine dehydrogenase, which functions in choline degradation.[6]


Function[edit] The mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate, linking glycolysis to the tricarboxylic acid cycle and fatty acid (FA) synthesis. Knowledge of the mechanisms that regulate PDC activity is important, because PDC inactivation is crucial for glucose conservation when glucose is scarce, whereas adequate PDC activity is required to allow both ATP and FA production from glucose. The mechanisms that control mammalian PDC activity include its phosphorylation (inactivation) by a family of pyruvate dehydrogenase kinases (PDKs 1-4) and its dephosphorylation (activation, reactivation) by the pyruvate dehydrogenase phosphatases (PDPs 1 and 2).[7]


Clinical significance[edit] As PDPR is involved in the regulation of the central metabolic pathway, its participation in disease pathophysiology is likely, but there has been no published research on this thus far.[5]


References[edit] ^ a b c GRCh38: Ensembl release 89: ENSG00000090857 - Ensembl, May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033624 - Ensembl, May 2017 ^ "Human PubMed Reference:".  ^ "Mouse PubMed Reference:".  ^ a b "Entrez Gene: Pyruvate dehydrogenase phosphatase regulatory subunit".  ^ Lawson JE, Park SH, Mattison AR, Yan J, Reed LJ (December 1997). "Cloning, expression, and properties of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase". The Journal of Biological Chemistry. 272 (50): 31625–9. doi:10.1074/jbc.272.50.31625. PMID 9395502.  ^ Sugden MC, Holness MJ (May 2003). "Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs". American Journal of Physiology. Endocrinology and Metabolism. 284 (5): E855–62. doi:10.1152/ajpendo.00526.2002. PMID 12676647. 


Further reading[edit] Sugden MC, Holness MJ (May 2003). "Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs". American Journal of Physiology. Endocrinology and Metabolism. 284 (5): E855–62. doi:10.1152/ajpendo.00526.2002. PMID 12676647.  Chen X, Li X, Wang P, Liu Y, Zhang Z, Zhao G, Xu H, Zhu J, Qin X, Chen S, Hu L, Kong X (August 2010). "Novel association strategy with copy number variation for identifying new risk Loci of human diseases". PloS One. 5 (8): e12185. doi:10.1371/journal.pone.0012185. PMC 2924882 . PMID 20808825.  Ohara O, Nagase T, Mitsui G, Kohga H, Kikuno R, Hiraoka S, Takahashi Y, Kitajima S, Saga Y, Koseki H (April 2002). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method". DNA Research. 9 (2): 47–57. doi:10.1093/dnares/9.2.47. PMID 12056414.  Lawson JE, Park SH, Mattison AR, Yan J, Reed LJ (December 1997). "Cloning, expression, and properties of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase". The Journal of Biological Chemistry. 272 (50): 31625–9. doi:10.1074/jbc.272.50.31625. PMID 9395502.  This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it. v t e Retrieved from "https://en.wikipedia.org/w/index.php?title=PDPR&oldid=821429575" Categories: Genes on human chromosome 16Human chromosome 16 gene stubsProteinsHidden categories: All stub articles


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Gene NomenclatureMouse Genome InformaticsHomoloGeneGeneCardsChromosome 16 (human)ChromosomeChromosome 16 (human)Chromosome 16 (human)Genomic Location For PDPRGenomic Location For PDPRLocus (genetics)Base PairBase PairChromosome 8 (mouse)ChromosomeChromosome 8 (mouse)Genomic Location For PDPRGenomic Location For PDPRLocus (genetics)Base PairBase PairGene OntologyEntrezEnsemblUniProtPubMedWikidataProteinGeneCDNABase PairNucleotideAmino AcidMg²⁺SpermineBLASTDimethylglycine DehydrogenaseCholinePyruvate Dehydrogenase ComplexPyruvateGlycolysisTricarboxylic Acid CycleFatty Acid SynthesisGlucosePhosphorylationPyruvate Dehydrogenase KinasePyruvate Dehydrogenase PhosphataseMetabolic PathwayPathophysiologyEnsembl Genome Database ProjectEnsembl Genome Database ProjectDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed CentralPubMed IdentifierDigital Object IdentifierPubMed IdentifierDigital Object IdentifierPubMed IdentifierGeneHuman Chromosome 16Wikipedia:StubTemplate:Gene-16-stubTemplate Talk:Gene-16-stubHelp:CategoryCategory:Genes On Human Chromosome 16Category:Human Chromosome 16 Gene StubsCategory:ProteinsCategory:All Stub ArticlesDiscussion About Edits From This IP Address [n]A List Of Edits Made From This IP Address [y]View The Content Page [c]Discussion About The Content Page [t]Edit This Page [e]Visit The Main Page [z]Guides To Browsing WikipediaFeatured Content – The Best Of WikipediaFind Background Information On Current EventsLoad A Random Article [x]Guidance On How To Use And Edit WikipediaFind Out About WikipediaAbout The Project, What You Can Do, Where To Find ThingsA List Of Recent Changes In The Wiki [r]List Of All English Wikipedia Pages Containing Links To This Page [j]Recent Changes In Pages Linked From This Page [k]Upload Files [u]A List Of All Special Pages [q]Wikipedia:AboutWikipedia:General Disclaimer



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